4 LOCAL ILSSLE REACTIVITY 



I hey iiicicK <j,a\c rise to pronounced celliilai' inlillialion hut 

 there was no hicakiii^ up ol the (eUs and no sexeie (hnnage to the 

 blood \cvssels. This is ilhistrated l)\ tiie lollowint^ experiment. 



IiG. 2. Raliliit treated in manner identical witli tliat represented l)v Figine i. 

 In this ral:)l3it there was a conflnent reaction extending from upper right and lower 

 right areas to tenter of skin of alKlomen. (Shwart/man, 192^/;.) 



Protocol 3: Rabbits 16-0, 16-1, and 16-2 received each four skin injec- 

 tions of tryptic digest Tl filtrate into the usual sites. Five-tenths cubic cen- 

 timeter was injected into each area. No reactions were seen in these rabbits 

 twenty-four hours after the injections. The same areas were then reinjected 

 with the filtrate. The amount of filtrate was again 0.5 c.c. for each area. 

 The readings were, then, made every hour for the following six hoins and 

 again fwenty hours later. About one to two hours after the reinjections there 

 appeared reddening and s^vellings in the four areas. The reddening became 

 very pronounced towards the end of five hours (4-}- erythema). Rabbit 16-1 

 was killed and sections of the inflamed skin were made. The following 

 nifjrning Rabljits 16-0 and 16-2 showed reactions of the same type as the day 

 before. They were then gi\en intravenous injections of tryptic digest T^ 

 filtrate in a dose of 3 c.c. per kilo of body weight. Four hours after the 

 intravenous injections both rabbits showed very extensive hemorrhagic 

 necrotic reactions which varied from 2x3 cm. to 3 x 4 cm. in size. 



