INTRODUCTION 5 



The skin section ol Rabbit 16-1 (i.e., receiving no intravenous injection) 

 showed inflammatory changes. There was an infiltration of polymorphonu- 

 clear ncturophile leucocvtes. The leucocytes did not appear necrobiotic. There 





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Fig. 3. Hematoxylin-eosin. X 230. Section of skin from Rabbit 14-1. Microscopic 

 appearance of hemorrhagic reaction five hours after intravenous injection of T. D. Tl. 

 Note necrol)iosis of white lilood cells. TShwartzman. 1928/?.) 



was no rupture of the blood vessels. No thrombi were fotmd. Some dilata- 

 tion of the blood vessels was seen in places. Tlie experiment Avas repeated on 

 eight more animals with identical results. 



Early observations on specificity of the phenomenon of local 

 skin reactivity to bacterial filtrates : 



As may ])e noted from the followino experiment, the skin 

 preparation with a given bacterial fihrate ^vas follo^vecl by tlie 

 intravenous injections of fihrates derived from l)iologically and 

 serologically imrelated microorganisms (i.e., B. tyljJiosus, lueiini- 

 gococciis, B. coll) . They unquestionably proved capable of sub- 



