b LOCAL 1 LSSLE REAC-TIVLLY 



stitutiiii^ lor one aiiolhcr pioxidcd llic) j)():ssessccl the power ol 

 i'li( iliii<j, llie plieiioineiion l)\' lliemsehes (Shwart/nian, 1928/;, 



^i t^t V**^ <^* # * # 



#;^* • «> •^ 4 « i •• ' *^ ^ f 







*f * • *#^«. A -' * ■• ' ••'1 ' '' 





I'lG. 4. Hemaluxylin-cosin. > 270. Section ot skin trom Rabbit 16-1. Mioostupit 

 appearance of reaction produced by repeated skin injections of T. D. I'l- No 

 necrobiosis of \vhite l)lood cells. (Shwart^man. 1928/).) 



Protocol 4: Twelve rabbits received each three simultaneous intradermal 

 injections of filtrates of certain microorganisins. The upper right areas ot 

 the skin of the abdomen of each of these rabbits were injected with 0.25 c.c. 

 of meningococcus culture filtrate ("A^q") , the lower right areas with 0.25 

 c.c. of B. typhosus culture filtrate ("Ajj^") , and the upper left areas with 

 0.25 c.c. of B. coll cuhure fihrate ("587") . Twenty-four hours later the rab- 

 bits were divided into 3 groups of 4 each. Each group received intravenously 

 a different filtrate. The rabbits of the first group received, per kilo of body 

 weight. 1.5 c.c. of "Aj,j" previously diluted 1:5, the second group received 

 1.5 c.c. of "Aj/' previously diluted 1:5, and the third group received 1.5 c.c. 

 of "587" previously diluted 1:5. Four hours later there were found 3 dead 

 rabbits in the first group. The () surviving rabbits showed severe hemorrhagic 

 necrosis ranging in size from 2 x 2.5 cm. to 4 x 4 cm. in all tlie three pre- 

 pared areas. 



