8 LOCAL TLSSUE REACTIVITY 



stead ol alter (lie ( u.sU)niai y (iNe lioins. The si^iiiluauee of tliis 

 obsei xalioii will he e(jnsi(leie(l suhscquenll). 



TERMINOLOGY 



Soon alier the ahoxe deseiil)e(I basic: experiments ^vere made, 

 it became necessary to select an appropriate terminology. Inas- 

 much as the exact natme of the oloservations was unknown, it 

 seemed advisal)le to choose a new terminology which woidd avoid 

 a preconceived association ^vith phenomena of anaphylaxis 'with 

 ^vhich there aj^peared to be a superficial resemblance. 



The phenomenon descriljed here is termed as the "])henome- 

 non of local skin reactivity to bacterial filtrates," ^vhen the pre- 

 j)aratory injection is made into the skin; or as the "phenomenon 

 of local tissue reacti\ ity to bacterial filtrates," ^vhen the prepara- 

 tory injection is made into other tissues or organs. 



Elicitation of the state of reactivity by means of a local injec- 

 tion into the skin or other tissues and organs of a potent bacterial 

 filtrate is termed as "preparation" and the factors capable of 

 eliciting this state are respectively called "preparatory" factors. 

 By the term "reactivity" is meant to imply the ability of a given 

 tissue to respond ^vith a typical lesion follo^viug the intravenous 

 injection of a potent preparation and is not designated neces- 

 sarily to associate this state with processes of anaphylaxis. The 

 terms "vulnerability" and "preparedness" are used alternatively 

 Avith the term "reacti\ity." Apitz (193-^^'') substituted the term 

 "reactivity" by "Ueberstimmiuig" ^vhich seems to be expressive 

 and for which I was inial)le to find an equivalent word in the 

 English language. 



As will be seen from the ^vork described in this monogiaph, the 

 essential prerequisite for elicitation of the reaction of the phe- 

 nomenon under discussion is that the second injection be given 

 via the blood stream. The factors invohed in production of local 

 hemorrhagic reactions following the intravenous injection ^vere 

 called "reacting factors." It may be ^vell then, to emphasize that 

 the term "reacting factors," employed here, is strictly limited to 

 substances capable of eliciting hemorrhagic reaction in the pre- 

 pared tissue upon their introduction into the general circulation. 

 Karsner and Moritz (19^34) introduced the term "provocative 

 factor" and Gratia and Linz (1932c) the term "facteius dechai- 

 nants." I believe, however, that it is safer to avoid the latter term 



