20 



LOCAL TISSUE REACTIVITY 



a txTtain anioiml ol actixe })rinciples injected into the vein of 

 the n()n-j:)iej)aie(l ear is lost in the general circulation before 

 reachiiiL!, liic skin of the j)rej)are(l ear. 



Im(.. 7. I'hfiionienon of local skin rcacti\it\ to nieniiigococciis filtrate in rabbit car. 

 (Mcnin.nococcus, Cironp III (44B) "agar washings" filtrate (T.1968) .) Twenty-five 

 hundredths cubic centimeter diluted 1:2 injected intradermally and 100 reacting 

 units injected intraveirously twenty-four hours later, (a) Typical lesion four hours 

 after intravenous injection. (/;) Control ear which received no preparatory injection. 

 (Sh\\'art/nian, 1935c.) 



In connection Avith the spreading of reactions beyond the pre- 

 pared sites, it is of interest to consider the following experiment 

 of Gratia and Linz: 



These authors gave an injection of a large preparatory dose of 

 B. coli filtrate into the dermis of the rabbit's ear followed 24 



Fig. 8. Treatment same as in Ear a of Figure 7. Note severe hemorrhage, edema, 

 inflammatory reaction and vascular thrombosis. X 50. (Shwartzman, 1935c.) 

 Fit;. 9. Treatment same as in Ear a of Figure 7. Section taken of area 3 cm. a\vay 

 from site of reaction and showing in gross cyanosis and edema. Note thrombi in 

 venules. X 400. (Shwartzman, 1935c.) 



