ROLE OF INFLAMMATION 1 85 



principles of the phenomenon into the same skin sites, at various 

 intervals of time, fail to produce the characteristic lesions. 



Tiie dmation of local skin reactivity to bacterial filtrates de- 

 pends a great deal on the potency of tiie preparation of bacterial 

 filtrates used (witli some preparations the reactivity lasts as long- 

 as one hundred and t\\enty hours) . It may be correlated to a fair 

 degree of accmacy with the phenomenon-producing titer of the 

 fdtrates. 



The acti\ e principles of the phenomenon injected intrax enously 

 promptly disappear from the blood stream. The question of their 

 fate remains open. 



