10)6 LOCAL ILSSLE REACniVITY 



nous injections ol |)itniliin into ( lainj)e(l ears aic prone to elicit 

 hemonliages. One lioui latei tliey may appear along the injected 

 \ein. Aj)pic)\iinately twenty lour hours later there develops cya- 

 nosis and pronomited hemoi rhai^e Avhich extend along the tribu- 

 taries ol the injected xeins. These reacticjns become more 

 pronounced il accompanied by intravenous injections ol menin- 

 gococcus Cirouj) III (44B) "agar washings" filtrate. The pro- 

 vocative injecticjn of active principles into veins oF ears thus 

 pre})ared brings about insignificant accentuation of primary re- 

 actions. It is obvious that the reactic:)ns may be interpreted as 

 primary damage to blood vessels ^vhich are not related tcj the state 

 of reactix'ity inider discussion. Possibly, similar effects were ob- 

 tained by Marcus (1920-21) and Schmidt-Weyland (i9^^2) . These 

 authors gave repeated injections of adrenalin into rabbits pre- 

 x'iously treated with bacterial tcjxins and, in some instances, they 

 obtained gangrene and thrombosis. 



It is of interest that in spite of the primary hemorrhagic le- 

 sions obtained Avith some of the mixtures above described, the 

 state of reactivity did not take place. 



Preparatory Intravenous Injections of Active Principles Accom- 

 panied by Application of Heat. Sausage shaped rubber bags filled 

 Avith Avater of the desired temperature were hrmly applied to both 

 sides of the ear for five minutes and preparatory injections were 

 given into the marginal \ein. In scjme experiments the ear was 

 clamped off at the base simultaneously Avith the application of 

 heat and the clamps Avere removed five minutes after the intra- 

 venous injections ^vere made. The provocative injections ^vere 

 given into the \ein of the same or of the opposite ear. 



Clamped and non-clamped ears exposed to 45°, 50°, 55° c. 

 for five minutes and injected Avith \arioiis amounts of actixe 

 bacterial filtrates intra\enously showed immediate intense hyper- 

 emia with subsecjuent swelling and moderate hyperemia t^venty- 

 four hours after the treatment. 



Pro\c)cati\e injections of bacterial filtrates in various amc^unts 

 elicited no secondary reactions in non-clamj)ed ears. 



The preparatory intraxenous injections of potent preparations 

 given into the veins of ears exposed to 45 \ 50' , 55^ c. and 

 clamped off at the base, were capable of eliciting the state of re- 

 activity of the phenomenon. Reactions following the pro\c)cative 

 injections were intense. Diffuse hemorrhages throughout the en- 

 tire ear were accompanied frecjuently by deep cyanosis. Micro- 



