220 LOCAL TLSSUE REACTIVITY 



inir.ixciioiis injcclion ol ilic same j)i iiu iplcs alter .i suitable in- 

 ter\al ol time. 



The leactixity oi the phenomenon also may be obtained by 

 \vay ol local \ascular siij)plv ("local \asciilar reactivity") and by 

 ^vay ot the t^eneral circidation ("general vascular reactivity") . 



Local vascular reactivity is elicited in the kidneys when the in- 

 jection ol the actixe principles into the renal \em is follo\ved 

 t went) lour hours later by the injection of the principles into the 

 ear \ein of the rabbit. 



The state of reactix ity cannot be elicited by a preparatory in- 

 travenous injection of bacterial filtrates alone into clamped and 

 non-clamped ears. The state also fails to appear in combination 

 Avith cold, xylol, ethyl urethane, pilocarpine hydrochloride, atro- 

 pine, calciiun gluconate, guinea pig liver extract, histamine dihy- 

 drochloride, adrenalin chloride, and pituitrin. Preparatory intra- 

 venous injections of active principles, however, are capable of 

 eliciting the state of reactivity in the rabbit's ear, Avhen they are 

 accompanied by thermal hyperemia (i.e., expostne to 45°, 50°, 

 and 55° c.) . It is also possible to induce the state of reactivity 

 when a mixture of preparatory factors with testicular extract is 

 given into the veins of clamped ears. The incubation period re- 

 quired may be less than two horns. 



The intravenous injection of either one or two doses of bac- 

 terial filtrate results in the appearance of venous thrombi and 

 degenerative changes in the niternal organs of rabbits. 



Renal lesions, however, consisting of thrombosis of the glomeru- 

 lar capillaries, focal tidjiilar necrosis and focal or diffuse cortical 

 necrosis, with necrotizing arteritis of the interlobular vessels were 

 found only when two intravenous injections of bacterial fdtrate 

 were given twenty-four hours apart (or several injections of 

 smaller doses over longer periods of time) . There exists an almost 

 complete parallelism l)etween this reaction of -the kidneys and the 

 phenomenon of local tissue reactivity xvhen the folloxving factors 

 in each reaction are compared, namely: macroscopic and micro- 

 scopic features of the lesions; regidarity of occinrence; suscepti- 

 bility of individual rabbits; time of appearance of lesions; neces- 

 sary interval of time betxveen the preparatory and pro\(icati\'e 

 injections; activity of preparations from various microorganisms 

 and susceptibility of animals other than rabbits (Apitz) . 



The fact that in the experiments where the state of reactivity 

 is elicited by way of the general circulation lesions characteristic 



