METHODS OF ELICITATION OF PHENOMENON 221 



ot' the phenomenon are obtained only in the kidneys is best ex- 

 plained by the assumption that the high permeability of renal 

 capillaries allo^vs the passage of the preparatory factors from the 

 general circulation into the kidney tissue, the formation of a peri- 

 vascular depot of the preparatory factors prior to elicitation of re- 

 activity being an essential requirement. 



Reactions characteristic of the phenomenon of local tissue re- 

 acti\ity also may be obtained by the combination of the prepara- 

 tory intravenous injection of li\'e bacteria and the provocative 

 intravenous injection of active principles of the phenomenon. In 

 these observations the local inflammatory reactions to live bacteria; 

 selective affinity of bacteria for various organs; and possibly, other 

 factors may influence the distribiuion of lesions (Sanarelli's 

 observations) . 



The intravenous injection of live staphylococcus into rabbits 

 previously injected intravenously with the active principles of the 

 phenomenon leads to acute endocarditis, the incidence of which 

 is considerably greater than in rabbits receiving no preliminary 

 treatment ^vith the active principles (Apitz) . This, possibly, may 

 be considered as an example of elicitation of reactivity in the 

 endocardiinu by way of the general circulation. 



The state of reactivity is also elicited in sites infected with live 

 bacteria {i.e.. Streptococcus Jiemolyticus, pneinuococcus, B. tuber- 

 culosis, B. antJrrncis, B. influenzae, B. Preitz-Nocard, Oidium al- 

 bicans, B. pseudo-tuberculosis, etc.) , and vaccinia virus. The re- 

 activity coidd not be elicited in staphylococcus lesions (i.e., a 

 microorganism producing only rarely the active principles of the 

 phenomenon) and was not observed ^vith viruses of herpes, 

 encephalitis lethargica and hydrophobia. 



