Cn A !• 11 R V 1 1 I 



REAClIVirV OF MALIGNANT NEOPLASMS 

 LO ACTIVE I^RINCIPLES OF THE PHENOM- 

 ENON OF LOCAL SKIN REACTIVITY 



INTRODUCTION 



THE j)ossible antagonistic effect of infections and l)acterial 

 ])rocliicts upon tumors has been noted by many investiga- 

 tors. Tiie ol)ser\ations pertain to the inllnencc ol infections 

 u})on transplantal)le and spontaneous mouse and rat neoplasms, 

 Rcjiis sarcoma, and human neoj)hrsms. Inasmuch as the experi- 

 mental topic cjf this chapter deals with the effect of bacteria and 

 their jDrodiicts only upon guinea pig, mouse, and rat neoplasms, 

 the re\'ie\v of the role of infections in Rous sarcoma and in human 

 tumors is presented only incompletely. 



In 1907, Beebe and Trac) considered as j)r()\ed the destructi\e 

 action exerted on certain types of tumor cells by bacterial prod- 

 ucts. Such action, ^vhile chiefly local, could also be oljserved ^vhen 

 the injection of the material ^vas made at some distance from the 

 tiunor. Dogs ^vere the experimental animal employed and the 

 tumor was a lymphosarcoma transplanted from a spontaneous 

 gro^vth removed at operation. 



Daels (1910) cjuotes pre\ ious obserxations of Loeffler on the 

 antagonism bet^veen tumors and malaria, and observatic:»ns of 

 Trautmann on the antagonism between tumors and relapsing 

 fever. The \v()rk of Daels was done with aheolar carcinoma origi- 

 nated from strains of Jensen's carcinoma. There ^vas usually about 

 80 per cent of takes. The tumor apparently developed very slo^vly, 

 inasmuch as the mice lived for nearly four months. Infectic:)n ^vith 

 the spirochete of tick fever in mice \vhich ended \\ithin approxi- 

 mately twenty to thirty days following the inoculation, protected 

 a certain proportion of the animals against carcinoma, especially 

 \vithin the pericxl of nine to tAventy-five days of tinnor inocula- 

 tion. The inoculated tumor seemed also to prc:>tect, to some ex- 

 tent, against the lethal effect of trypanosoma infections. 



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