REACTIVITY OF MALIGNANT NEOPLASMS 22^ 



Ri\xMs and Peaice (1925) reported that \'irus III and \ actinia 

 virus inultij)lied in a transplantable rabbit tumor of ejMthelial 

 origin and, despite an immunity developed by the rabbit host, 

 the viruses survived longer in the tumor than in the testicles oi 

 normal rabbits. The viruses apparently had no ettect upon the 

 tumor growth. 



Centanni and Rezzesi (h)2()) . who worked with a very limited 

 group of mice (a])out ^] to () mice in a group) concluded that there 

 existed a certain antagonism between tuberculosis and the de- 

 velopment of experimental adenocarcinoma. WHien an active 

 tuberculous infection ^vas aborted, the latent tmnor de\'eloped 

 and the animal became susceptible to a subsecjuent transplant. 

 Since the authors did not observe the antagonistic effect with 

 dead Ixacilli, it was suggested by them that the antagonism was a 

 function of an allergic state established by an active tuberculous 

 infection. 



Lazzarini (1927) concluded that sporotrichvmi infection had 

 no influence upon the evohition of tar cancer in mice. 



Comsia (1928) transplanted Ehrlich's carcinoma into mice 

 ^vhich prexiously ser\ed for conservation and passages of the 

 spirochete of relapsing fever. He noticed that the transplants 

 developed very irregularly in the infected animals instead of 

 grooving jDromptly and regularly as in normal animals. Although 

 the experiments ^vere carried out only on a few mice, it seemed 

 to him that there existed a correlation between the degree of 

 spirochetosis and regression of transplantable tumors. This author 

 also pointed out that the tumor which under^vent successive pas- 

 sages through a nrmiber of animals previously infected by re- 

 lapsing fever, developed ^vith more difficulty or did not appear 

 at all when transplanted into a normal animal. 



Cherry (1929) studied the effects of subcutaneous inoctdation 

 of small numbers of tubercle bacilli on the incidence of spon- 

 taneous tumors in a series of 96 Avhite mice. The normal inci- 

 dence of tinnors in his stock of mice ivas approximately 6 per 

 cent. After inoculation Avith B. tuberculosis, it rose to 55 per cent 

 in the males, and 71 per cent in the females. About one-third of 

 these ttnnors was mesoblastic and two-thirds were of epithelial 

 type. This series of neoplasms differed in range of type and situa- 

 tion from any hitherto recorded in mice, i.e., those arising in the 

 thyroid, pvlorus, colon, prostate, pancreas, and bladder. The mice 

 also exhibited an associated syndrc:)me of lymj)h()i(l changes. The 



