REACTIVITY OF MALIGNANT NEOPLASMS 229 



days ot tumor growth. Mice IX, X, and XII received in addition intravenous 

 injections of the same dose on the thirtieth and thirty-fourth days of timior 

 inocuhition. Here again, the first injection elicited severe hemorrhage in 



Fig. 20. Mice bearing tuehe dav old sarcoma 180 recei\ed each 100 units of B. 

 typhosus "agar washings" filtrate intravenously. Note severe hemorrhage in tumor tis- 

 sue four hours later (a, b) ; and twenty-four hours later (r) ; dry hemorrhagic crust 

 two days later (d) and four days later (e) , and healing of lesion eight days later 

 (/) . (In a. tumor is cross-sectioned.) (Shwartzman, 1936/?.) 



twenty-four hours. Finally, Mouse IX showed complete regression Avhich was 

 follo\\cd by scab formation. There was, howe\er, a doiibtfid gTO^\•th observed 

 at the borders on the thirty-seventh day of tumor inoculation. The tumor 



