2^8 lOCAI, TISSUE REACTIVriY 



ol l()(;il tissue leadixit) in the niaiciial used. This (onteution is 

 brought out clearly by (onipaialive studies ou the etteet ol active 

 j)iiiuij)les and a variety ol non-bacterial substances. 



It had previously been shoxvn by Kubo (lO'^o) and by Lattes 

 (ic)'Vj) that inllaiiiination asejitically jiroduced with oil ol tui- 

 pentine and diatoniaceous earth exerts but little influence upon 

 the late ol t^roxvth ol transplantable tumors. 



It Avas shown by Heubner (1907) that gold chloride in a 

 large dose kills rabbits and cats \vithin a fexv minutes. The death 

 is due to cessation of respiration, the heart continuiii" to beat for 

 a few moments. The arterial blood pressure drops very pr()mj:)tly 

 and may reach zero ^vithin ten minutes. Antopsy shows dilatation 

 of all the veins of the body. The finest blood vessels appear in- 

 jected. A prononnced hyperemia is observed in all the serous and 

 mucous membranes, especially in the abdomen. The smface of 

 the liver, spleen and kidneys shows irregular hemc^rrhagic spots. 

 On secticjn, the l^lood oozes profusely from parenchymatous or- 

 gans, lungs and muscles. Frequently, the peritoneal cavity con- 

 tains free blood. The artericjles are irsually strongly constricted, 

 whilst the capillaries and the veins are dilated. The picture of 

 intoxication, as studied by Heubner in the frog, may be descriloed 

 as a severe dilatation and opening of all the capillaries of the body 

 or capillary bleeding associated xvith cc^nstriction of the arterioles 

 and. therefore, resembling xery much the picture of traumatic 

 shock and also that of histamine intoxication. The fall in blood 

 pressure is explained by Heubner as a complete relaxation of the 

 capillaries xvhich ])rings abcjut emptying of the arterial circida- 

 tion. Witte's peptone is also kno^vn to be capalole of producing 

 protracted shock and collapse of the circidation. Histamine elicits 

 acute death following the injection of 0.03 mgms. per 1 gm. of 

 body x\ eight. Crotnlus adenanunitiis, in a dose of 0.007 to 0.008 

 mgms. per gm. of body 'weight, produces midtiple hemorrhages 

 in the serous membranes and internal organs of the mouse xvithin 

 six tc^ txventy-tour hours following the injection. 



The abo\'e sidjstances xvere tested by Apitz (ig^^c) in tumor- 

 bearing mice. In sj)ite of the severe hemorrhagic lesions obtained 

 in organs and prompt lethal effect of some of the substances 

 tested, none of them xvas able to produce any hemorrhagic lesions 

 in the tumors. It is interesting that the injection of Cyotaliis ade- 

 naiiii'iitiLs and gold chloride in the doses employed produced the 

 typical picture of hemc:)rrhagic diathesis in all the organs, -with 



