REACTIVITY OF MALIGNANT NEOPLASMS 245 



free from infection Avith B. eiiteritidis ^vas inoculated with mate- 

 rial from a sterile tumor. The timiors de\eloped normally in both 

 grouj)s of mice. 





Fig. 24. Section of twelve day old tiny necrotic sarcoma 180 in mouse with sponta- 

 neous infection of B. enteritidis. Note evidence of severe hemorrhage and necrosis of 

 tumor. X 220. (Shwartzman, i936«.) 



EFFECT OF INDUCED INFECTIONS ON DEVELOPMENT OF 

 MOUSE SARCOMA 180 



In these experiments live ctiltures and culture filtrates of B. 

 enteritidis and Staphylococcus aureus were employed for intrave- 

 nous injections into normal mice and mice bearing twelve day 

 old sarcoma 180. 



