2^6 LOCAL ILSSLL RLACTIVLIY 



injmioiis ctlcds ol badcrial siihstaiu cs ol primary toxicity than 

 the blood \cs,scls ol noinial tissue. It is (liliuiilt to explain, how- 

 e\er, \\\\\ such strong capillaiy poisons as i^old (iiloiide and 

 Croldlu.s (uleuamcntus, fail to affect ihe neojjlasiiis whilst destroy- 

 ing normal capillaries. P. Border injected talcum intraperito- 

 neally and foiuid that the granulation tissue formed in sites 

 where talcum Avas deposited became hemorrhagic following the 

 intracardial injection of bacterial active principles (talcum 

 failed, however, to produce the state of reactivity in the skin) . 

 According to P. I^jordet this points to the theory that the young 

 capillaries of the granidation tissue are susceptil)le to the active 

 principles of the phenomenon similarly to the cajjillaries of the 

 neoplasms. Evidence vvas brought forth, ho\ve\cr, that granula- 

 tion tissue produced by painting Avith croton oil (p. 156) , and 

 also various granulomas, teratomas and all benign tumors are 

 totally resistant to the active principles of the phenomenon 

 (Dtiran-Reynals, 1933-34, 1935) • 



The bacterial secondary infections of timior-bearing animals are 

 well known. It has been assumed by some investigators that these 

 invaders may be responsible for the reactivity of tiniiors. Dman- 

 Reynals (1933/'') . howexer, fotmd that timiors in which there vvas 

 never observed a bacterial infection reacted strongly to the effect 

 of the active principles. It is also of interest in this connection that 

 the reaction may be obtained in yoinig sarcomas (six to ten days 

 after transplantation of sarcoma 180) at the time when no ulcera- 

 tions are seen and the blood, organs and the tumor tissue of the 

 mouse are sterile. It may be seen from the above discussion that no 

 acceptaf)le explanation can be offered as yet for the reaction in the 

 tumors to the active principles of the phenomenon under con- 

 sideration. 



RFXIAPITULATION 



Intravenous injection of active principles of the phenomenon 

 into tinnor-bearing guinea pigs, mice and rats induces severe 

 hemorrhagic necrosis in the tinnors with subsec]iient regression 

 in a high percentage of animals treated. 



Positively reacting tmncjrs include raj:)idly growing malignant 

 transplantable tuiiiors, tar tinnors, and possibly, malignant spc:»nta- 

 neous timiors. Negatively reacting tumors ccjnsist of comparatively 

 slowly grooving spontaneous or transplantable malignant tumors 



