^]2^ LOCAL ILSSLE REACTIVITY 



aiiioimi ol iniimmc scniiii to tlic lillratcs may, however, inactivate 

 tiie letiial lactois lea\in<^ tlie jjlienonienon-prodiu iiiL; j)oteiuy lui- 

 iiiipaiied. 



The acti\e j)iiiKi])les ol the plienomenon clearly differ ironi 

 anaphylatoxins. The lack of correlation is based on the differences 

 in susceptibility of species; inability to produce reacting potency 

 /// vitro by expostne to agar; inactivity of sensitized ox red blood 

 cells; lack of potency in agar devoid of nitrogenous substances; 

 inactivity of defibrinated blood; failure of distilled water and 

 defibrinated blood of sensitized rats treated with distilled water 

 to elicit reacting potency in sera of immune animals; inactivity 

 of a variety of non-bacterial substances; failiue of sodiimi carbon- 

 ate to protect against the phenomenon; and also on the absence 

 of any relation between the complement to the activity of the 

 antigen -j-antibody complexes. 



No conclusive experiments have been made as yet to determine 

 whether the Forssman antigen-[-antibody complexes may act as 

 reacting factors similar to the combinations of the animal proteins 

 with antibodies. 



The pinptna-producing properties of anti-platelet sera are 

 totally devoid of the active principles of the phenomenon. 



