338 LOCAL TLSSUE REACTIVITY 



iciiiaiiis uiikiiown as yet. Dman-Rcynals (\()2(), i9-5'V) icpoi led 

 on the iJicsciKc ol ,s|)rc'a(liii^ ra( tors ca|)al)lc ol ciiliaiuin^ tissue 

 pei'nieal)ility in l)acterial filtrates. It is j^ossible that an intra- 

 \enous injection of a bacterial filtrate accompanying^ the skin 

 prejiaration may enhance the rate of cliftnsion ol the material 

 injected locally through increase in the capillary or lymphatic 

 permeability. The preparatory factors thus diliited might not 

 bring al30iit a state of reactivity. Gross and histological examina- 

 tions of the tissue in \vhich reactions had been inhibited did not 

 disclose thus far any spreading phenomenon. 



The inhibition of the phenomenon demonstrated by Ogata 

 cannot be interpreted as an anaphylactic desensitization for the 

 following reasons: 



1. Inhibition takes place when the additional intravenous in- 

 jection is given simultaneously or shortly before and after the 

 preparatory injection. Obviously, an anaphylactic desensitization 

 cannot be expected to occur before sensitization is induced. 



2. There is no specificity of inhibition. 



The imminiization of animals ^vith the active bacterial prin- 

 ciples of the phenomenon brings about a refractoriness to the 

 phenomenon. The analysis of these experiments definitely indi- 

 cate that the refractory state is more allied with active acquired 

 immunity than with desensitization, inasmuch as in rabbits of 

 high susceptibility the combined intradermal and intravenous 

 immunization with graded amounts may elicit specific immunity 

 against the factors used for immunization, leaving unaltered the 

 ability of the same rabbits to react ^vith heterologous active 

 principles. 



A priori the lack of passive transfer of reactivity of the phe- 

 nomenon under discussion may be expected because the anti- 

 bodies produced by immunization with the active principles are 

 capable of complete neutralization of these principles in vivo. 

 The larger the- amount of the antibody employed the greater 

 is the amount of active principles necessary for the elicitation of 

 the phenomenon. Thus, in contrast to anaphylaxis, the antibodies 

 play the protective, but not the sensitizing role. 



In my o^vn early studies I reported a series of experiments on 

 the lack of passive transfer of reactivity of the phenomenon un- 

 der discussion. The attempts to transfer passively the local skin 

 reactivity were made by using various batches of antityphoid im- 

 mune sera derived from various animals (goats, horses, and 



