'^()() LOCAL TLSSIIE REACTIVLIY 



Sor^o (i()ii) {'laiiiK'd lliat diplil lici ia, (l\scnlc'i\, and ( liolcra 

 toxins <>i\c' skin reactions which aic j)aielk'l both in incidence 

 and in intensity with tiie tul)eiculin reaction. This claim was 

 contradicted by /ieler (kjii), who lonnd that the reactions to 

 B. (lyseiilc) iac and B. I\jjh(>.sti.s cultme filtrates, while often large, 

 are atypical and rajjidly lading while theii incidence is not strictly 

 parallel to that of tidjercidin sensitivity. 



Ugrinniow (1928) observed a protracted shock lollovving the 

 injection of a non-toxic dose of B. culi fUtrate in animals treated 

 twenty-foin- horns })revionsly by an intravenotis injection of India 

 ink, collargol and trypan bine. 



The (jnestion of protracted and inmiediate anaphylactic shock 

 in tidoercidoiis guinea pigs received seriotis consideration in the 

 vvork of Dienes (1929-30). 



He fotnid that tid)ercidoiis guinea pigs sensitized to egg al- 

 binnin go into protracted shcjck foUovving injection of egg al- 

 binnin, the symptoms showing great similarity tc3 the tubercidin 

 shock. The most striking hnding at the autopsy is an abinidant 

 exndate in the peritoneal cavity and hemorrhagic lesions in the 

 peritoneimi and at the sites of the tnbercidons lesions in the 

 omentimi and mesentery. 



According to P. Bordet (1936^) , guinea pigs inoculated vvith 

 B.C.G. are more susceptible than normal guinea pigs to intra- 

 peritoneal injections of B. coli. The animals show also severe 

 acute hemorrhagic lesions in various organs. 



Sanarelli demonstrated hemorrhagic lesions and aciue shock in 

 rabbits infected with Vibrio cJiolerne and subsequently injected 

 with B. coli ciUture filtrate. 



My observations jioint to the fact that induced B. cntcritidis 

 infections and spontaneous secondary infections of tumor-bearing 

 mice (Chapter vni) raise considerably the lethal effect of B. ty- 

 phosus, meningococcus, and other bacterial filtrates. Animals die 

 in a condition of protracted shock from one to six or seven days 

 following the injection. (Shwartzman, i936rt.) 



To Sinn up, the following features differentiate bacterial allergy 

 from anaphylaxis: Dependence of the sensitivity upon an infiam- 

 matory reaction of the tissue follovving the injection of living 

 fjacteria and certain Ijacterial products; the delayed and strongly 

 inflammatory hemorrhagic and necrotic types of local and focal 

 lesions; questionable passive transfer; doubtfid neiUralization of 

 cutaneous sensitivity; and abnormal hypersensitiveness to foreign 

 proteins (hetero-allergic reactions) . From studies on bacterial 



