^^7<> L()c;al iissi'K REAcrivriY 



B. l\jj/i(>Mi\ ri'iutiii^ hutois. ,\,s was seen, in iinimiiii/ation ol 

 horses A\illi B. IxjjIio.sii^, ineiiin^ocoi ( us, and li. (oli (ulture fil- 

 trates, uncorrelated Ihu tuations ol the a,<i„L!,hitinin and neutrahzing 

 titers ol the sera are ohserxed (dhajJlers iv and \ni) . Reiter 

 and Silhersteni (i()ir,) noted that in inninuie sera prochiced by 

 iinmuni/ation with l)phoid vaccines ]Mej)ared in \arious ways 

 there was no j)aiallelisni between the titers ol agglutinins and 

 bacteri()tr()j)ins. 



Normal human sera, in Klein's (h).^'^) experiments gave con- 

 sistent neutralization of 25 B. typliosus reacting units. This was 

 considerably greater than the potency of normal serum in neu- 

 tralizing gonococcus or meningococcus reacting" factors. Since nor- 

 mal serum is luiequally potent in neutralizing various bacterial 

 filtrates, it is necessary in evaluating the neutralizing potency of a 

 serum to compare the results obtained with the potency of nor- 

 mal serum in the neutralization of the reacting factors in (juestion. 



The valtie of this author's observations seems to be iirst in the 

 demonstration of a gradual increase in the amotuit of neutraliz- 

 ing antibodies during infection, and secondly, in the presence of 

 a titer of neutralizing antibodies well above normal expectancy at 

 the time of convalescence. 



RKI.ATION OF THE PHENOMENON OF LOCAL TLSSUE REACTIVITY 

 TO HEMORRHAGIC DIATHESIS 



Some of the conditions as classified by Pratt (1927) under the 

 title of hemorrhagic diathesis need consideration in this mono- 

 graph, namely, essential thrombocytopenic purpura; symptomatic 

 thrombocytopenic purpura following infections and anaphylaxis; 

 non-thrombopenic purpura (anaphylactoid purpura, Schoenlein- 

 Henoch disease) and the non-thrombopenic ])ur])ura f()llo^ving■ 

 infections. 



The conspicuous feature in essential thrombocyto])enic ])ur- 

 pura is diminution in the number of thrombocytes. Other symp- 

 toms of considerable importance are multiple hemorrhages in the 

 skin, mucous memloranes, ovims and intestinal bleedings. In ad- 

 dition to diminution of blood platelets there is prolonged bleed- 

 ing time. On the other hand, the coagulation time in vitro is nor- 

 mal or only slightly prolonged. Retraction time is also consider- 

 ably prolonged. The "tourniquet" test demonstrates clearly an 

 increased capillary fragility. Slightest injury may produce skin 

 hemorrhaoes. 



