SIGNIFICANCE OF PHENOMENON 383 



given, Apitz (i9^^4<7, 1935^) succeeded in obtaining the lesions 

 in pregnant animals following the intravenous administration of 

 only a single injection. In similar experiments in my laboratory, 



-■-'.■•i% --'«*•.• A'-?l$i/ ' *^^,.-|** ^^ 



*•*■'> -'^^-i wr>^^ ^i"^/N» V -.•■ • *# /^\> ^j ' : 



Fig. 39. Autopsy study in a woman aged tuenty-tuo: acute thrombocytopenic 

 purpiua. Platelet thromlnis within arteriole of kidney. See also illustrations in 

 article by Baehr, Klemperer and Schifrin (1936) . 



the kidney alterations ^vere obtained once in 10 pregnant animals 

 used. Apitz considered pregnancy to represent a state of general- 

 ized reactivity comparable to that obtained experimentally by the 

 introduction of the first dose of bacterial filtrate so that only a 

 single dose Avas recjuired to elicit the phenomenon. The patho- 

 genesis of bilateral cortical renal necrosis in pregnancy in htmians 

 has been considered by Scriver and Oertel (1930) to be related 

 to a general state of abnormal \'asomotor irritability. 



The occurrence of thrombotic lesions in the arterioles, venules 

 and capillaries in the internal organs in infectious and toxic states 

 in humans has lono been knoAvn and has often been referred to 



