384 LOCAL ILSSUE REACTIVITY 



as t()\i( tliioiiihosis. Kxpei iinciUs uiulcrtakcn by Kiisaina (i<)i'',) 

 to explain the nature ol these thiombi revealed that, among other 

 things, the injection ot bacterial \accines would elicit such \ascu- 



FiG. 40. Swine. Hog 



cholera: inan\ glomeruli with caj)illar\ thro 

 Klemperer and Cierber, 19.36.) 



nihi. (Shwart/'inaii, 



lar throml)osis in rabbits. Subsequently, Siegmund (1925) who 

 had observed similar thrombi in chronic sepsis in humans suc- 

 ceeded in producing these lesions in animals by the repeated in- 

 jection of bacterial vaccines over a prolonged period of time 

 {B. coll, streptococcus, etc.) followed by live organisms. He con- 

 sidered the thnmibi to be the result of endothelial damage due 

 to sensitization ])y the vaccines and postulated that an identical 

 mechanism ^vas operati\e in chronic infections in humans. 

 Klemj^erer has seen similar thrombotic lesions in a variety of 

 chronic infections. Bacteria ^vere not foinid in the thrombi. It is 

 questionable ^vhether or hot such lesions in organs other than 

 the kidney should also he interpreted as the result of an altered 

 vascidar response, since Apitz, and Gerber ^vere able to produce 

 similar thrombi in the internal organs of rabbits exclusive of the 

 kidneys by the intravenous injection of a single dose of bacterial 

 filtrate. 



