SIGNIFICANCE OF PHENOMENON 385 



Tims, the 11101 pholooit similarity mentioned here between the 

 experimentallv j)i<){lnced tissne ehanoes and certain morbid proc- 

 esses in hnmans suggest a related mechanism in the pathogenesis 



• v * «* < 



I 







W'j -H^ 



Fig. 41. Autopsy study in iutant aged eighteen months: generalized miliary tu- 

 Ijcrcuiosis. Glomerukis with granular thrombi within dilated capillaries. (Shwartz- 

 nian. Klemperer and Gerber, 1936.) 



ot the latter. It is realized that in spontaneous infections there 

 may be expected deviations from the optimum conditions neces- 

 sary for elicitation of the phenomenon of local tissue reactivity 

 in the rabbit, namely, in the quantitative relationships of the 

 preparatory and provocative factors; in the degrees of active and 

 passi\'e immunity of tissues; and in the potency of active prin- 

 ciples produced. It shoidd be also considered that in addition to 

 lesions elicited by the mechanism described, there are most likely 

 superimposed the specific toxic effects of the invading micio- 

 organisms (cytolytic, fibrinolytic, and other substances) . 



It may be also in place to suggest the possibility that thrombi 

 carrying bacterial or toxic factors present in the blood stream in 

 cases of sepsis when caught in the capillaries induce a state of 

 reactivity at the site of their lodgment. Subsequent discharge of 

 toxins or bacteria from the infected focus may, then, be able to 

 produce hemorrhagic lesions in the tissues prepared by these 

 thrombi. In this manner it may be possible to exj^lain the origin 

 of such types of diffuse hemorrhagic lesions as are observed in 

 meningococcus sepsis. In most instances, the meningococci may 



