392 LOCAL ILSSLE REACTIVITY 



1 he phenoiiK'iion ol hxal tissue reactivity allows e\j)ei inieu- 

 tal rej)i()(luc tion ol lienion liable diathesis (oiisistiut; ol (ajMllaiy 

 liability and thionibus roiiiiatiou which may extend beyond the 

 local lesion. 



Inhere exists a definite nioi j)holot>ical and clinical similarity 

 between these experimental lindings and certain conditions of 

 hemorrhagic diathesis and hemorrhagic infectious diseases. 



Production of severe lesions through the synergistic effect of 

 biologically unrelated microorganisms and also through the 

 synergistic effect of microorganisms and non-bacterial antigen-]- 

 antibody complexes suggest explanations for the pathogenesis of 

 certain secondary and mixed infections and also for exacerbations 

 of bacterial diseases. 



