414 LOCAL TLSSUE REACTIVITY 



Scrum Miknc.s.s. I-'atililics for llic toiuentralion ol the anti- 

 typhoid antitoxic sernm were not readily avaihd)le. It was neces- 

 sary, therefore, to employ large quantities of iniconcentrated 



OAVS OF DISEASE 



Fig. 45. Temperature Chart III. Case C. li. 



serinn. The intraxenous injection of such large quantities of horse 

 serimi residted in the subsequent development of clinical mani- 

 festations of serum sickness in a large proportion of the cases. 



The first manifestations of serinn sickness began, as a ride, on 

 or about the sixth day after the first injection. The symptoms in 

 order of their frequency were fever, urticaria, tachycardia and 

 arthralgia. The serum sickness persisted for t^vo to five days. It 

 sho^ved a tendency to recur on or about the t^velfth to fourteenth 

 and on the eighteenth to twenty-first days after the injection. The 

 second and third bouts ^vere sometimes more severe than the 

 })rimary attack. 



The symptoms of serum sickness were seldom alarming, but 

 they brought discomfort to the patient and often ol)scined the 

 clinical picture during the stage of recovery. The fever ^vhich 

 usually accompanied the serum sickness frequently made it diffi- 

 cult or im])ossible to interpret the infiuence of the therapeutic 

 serum upon the temperature curve of the typhoid fever. This is 

 illustrated by the follo^ving temperature curve of a normal, 

 afebrile \olunteer, Avho received an intravenous injection of 400 

 c.c. of anti-typhoid horse serum. 



