.[2U LOCAL ILSSLE KEACIIVLIY 



and all paiicnts uihIci went the llic'iaj)cini( (oiusc with ciiictuic 

 w itiioiit improxcmcnt. 



OtiUonic. Ill 18 ol the 21 cases treated, the results were good. 

 In fact, hi ir, cases the iinproveinent was strikini) as evidenced 

 by al)ruj)t chop in temperature, reduced nuiiiher ol stools and 

 clinical \\ell-being oi the patients ^vithin Iroin two to six days. 

 In these j3atients, the stools became loiined and, sigmoidoscop- 

 ically, the ulcerations had disappeared in Irom two to three 

 weeks. In ^^ other cases the improvement xvas noted in one to 

 tiiree \veeks. The remaining •■>, cases ^vere considered therapeutic 

 lailures. One ol these ■;] failures developed a peri-sigmcjid abscess, 

 even thotigh the mucosal idcers healed. In another case, the 

 seriun was administered early — on the tenth day of a very septic 

 course. A study of the toxin of this })atient's B. coli revealed an 

 absence of neutralization by the serum used. Ten cases have been 

 folloxved for from six months to one year. T'^vo of this group ex- 

 perienced mild reciurences, one at seven months and one a year 

 after treatment. 



In the Mt. Sinai Hosj)ital polyvalent, anti-dysentery hcjrse 

 serinii and Bargen's concentrated serimi have been administered 

 repeatedly to patients xvith non-specific idcerative colitis. We ha\'e 

 not been impressed favc:)rably by the residts. However, inasmuch 

 as ecjuivalent amoimts of sera were not used, this series is not con- 

 sidered a proper control to the series with the anti-coli sertmi. 



A complete consideration of these cases and the therapy em- 

 ployed xvill not be given in this monograph. No claim is made for 

 the etiologic role of B. coli in this disease. It may be a factor of 

 significance as a primary or secondary invader, or it may not par- 

 ticipate in causing or maintaining the infection. The therapeutic 

 restdts obtained may have been due to a non-specific influence of 

 the large amount of horse sertun administered Avithin a short 

 period c:>f time. We are led tcj present a preliminary statement on 

 the residts with this serum because (1) its use seems logical, (2) 

 the results in this fairly large group of seriously ill patients ap- 

 pear unusually satisfactory, (■■]) the method of treatment c:>ffers a 

 new line of inxestigation and therajDy of a baffling malady, and 

 (4) since the non-specific, protein reactions (chills and elexations 

 of temperature) ^vere observed only in a few instances, appar- 

 ently they ^vere not responsible for the amelioration of the ail- 

 ment. 



In the ftUure it may be advisable to {prepare a serum in Avhich 



