APPLICATION OF THE PHENOMENON 425 



marked relief from toxemia and a favoraf)le effect upon the course 

 of the disease. Tliere also appeared to be a reduction in mortality. 



Assuming on the basis of the experimental data presented in 

 this monograph that non-specific idcerative colitis may render the 

 tissues receptive to the effect of natural loacterial inhabitants of 

 the body, phenomenon-neutralizing anti-col i sera Avere used for 

 treatment in these cases. In 18 of the 21 cases treated the results 

 were favorable. Inasmuch as non-specific protein reactions ^vere 

 observed in only a few instances, they were not considered re- 

 sponsible for the amelioration of the malady. 



Peck and Sobotka observed that snake venom may elicit a non- 

 specific refractory state to the phenomenon of local tissue reactiv- 

 ity and considered this an indication of its ability to enhance the 

 resistance of the capillaries. On the basis of these observations, 

 snake venom ^vas used for treatment of cases of hemorrhagic dia- 

 thesis by Peck and Goldberger and reciuTent epistaxis by J. L. 

 Goldman. There ^vas obser\'ed a beneficial effect in a certain 

 percentage of cases. 



