468 Physiology 



PHOSPHOHEXO- 

 ISOMERASE 



glucose 



11 HEXOKINASE. ATP 



glucose- 6-pho5pfx3te 



f ru cf ose-6 -phosphaf e 



PHOSPHOHEXOKINASE. ATP 



V 



fructose -1.6 -diphosphate 



ALDOLASE 



o-g!yceraldehyde-3- 

 phosphote 



TRIOSEPHOSPHATE- 

 ISOMERASE 



TRIOSEPHOSPHATE DEHYDRO 

 GENASE, 

 PHOSPHATE 



1,3-diphosphoglyceric acid 



PHOSPHOGLUCO- 

 MUTASE 



glucoTe- 1- phosphate 



PHOSPHORYLASE, 



PHOSPHATE 



stored 

 polysaccharide 



^ dihydroxyacetone- 

 phosphote 

 A 



cx-GLYCER0PH0S~ 



PHATE 

 DEHYDROGENASE 



PHOSPHOGLYCERIC 

 TRANSPHOSPHORYLASE. 

 ADP 



3- phospho-D- glyceric acid 



PHOS PHOG LYC E RO M UTA S E 



V 



2- phospho-D -glyceric acid 



ENOLASE 



phospho-enol- pyruvic acid 



PHOSPHO PYRUVATE 

 TRANSPHOSPHORYLASE. 



ADP 



pyruvic acid 



L-w- glycerophosphate 



PHOSPHATASE. 

 H,0 



glycerol ♦ 

 phosphate 



Fig. 8. 3. Dissimilation of glucose. 



phosphates (63). Glycolysis is similar in T. evansi (379) and T. hippicum 

 (194). In the latter, hexokinase, aldolase, triose-phosphate dehydrogenase, 

 glycerol dehydrogeanse, and glycero}>hosphate dehydrogenase have been 

 demonstrated. The activity of hexokinase in certain trypanosomes is in- 

 hibited significantly by arsenicals (194, 379) and in malarial parasites by 

 quinacrine (22, 534). 



The products of dissimilation vary in different species of Trypanosoma 

 (31). Certain species decompose glucose mainly, or even quantitatively 

 (194), to pyruvate. Trypanosoma equiperdiun (475) produces pyruvate 

 and glycerol; glycerol accumulates under anaerobic conditions but is con- 

 verted almost completely to pyruvate aerobically (475). Sugar metabolism 



