Malaria 607 



ing upon the strain, 12-24 daughter nuclei are present. After merogony, 

 rupture of the corpuscle liberates the merozoites, and the survivors enter 

 fresh corpuscles. 



After a time, mature gametocytes appear in the peripheral blood. The 

 cytoplasm of the larger (8-10[j,) macrogametocyte usually stains a fairly 

 deep blue (Wright's stain); that of the smaller (7-8[ji,) microgametocyte, 

 a pale blue. The nucleus of the former is comparatively small and stains 

 a rather deep red, or sometimes bluish-red. The larger nucleus of the 

 microgametocyte is stained light red or pink. Numerous small brownish 

 pigment granules are distributed throughout the cytoplasm of the micro- 

 gametocyte. The larger and fewer pigment granules of the macrogameto- 

 cyte are often concentrated in the peripheral cytoplasm. Both types of 

 gametocytes practically fill the enlarged corpuscle at maturity. 



Erythrocytic phase in P. falcipariwi (Fig. 13.3). Merogony is usually 



Fig. 13. 3. Plasmodium falciparum, seniidiagrammatic: A. Young ring. 

 B. Ring ^v'ith two masses of chromatin. C. Double invasion of a corpuscle 

 in which Maurer's dots are indicated. D. Corpuscle with four young para- 

 sites. E. Older ring; corpuscle shows Maurer's dots. F. Two growth stages 

 in a corpuscle. G-I. Binucleate and multinucleate schizonts. J. Merozoites. 

 K. Undifferentiated gametocyte. L, M. Microgametocytes. N. Macrogameto- 

 cyte. 



