OF THE ALIMENTARY TRACT 71 



testis and its tract and Warsley and Bateman (1924), 

 Craig (1911), Macfie (1916) and others have ob- 

 served it in the urine. Kofoid (1925) and others 

 have reported finding Endamocba histolytica in duo- 

 denal drainage from cases of intestinal amoebiasis 

 without liver abscess. 



While it may escape the bounds of the intestine and 

 the portal circulation, such accidents are unusual. 



The finding by Kofoid and his co-workers of bodies 

 which they took to be Endamoeba histolytica in the 

 joints of arthritis deformans and the lymph nodes of 

 Hodgkin's disease has not been generally accepted 

 as correct. The writer has had no opportunity to 

 attempt confirmation of their observations except in 

 fresh lymph nodes of Hodgkin's disease. There no 

 amoeba was found. Kofoid identified the cells which 

 he found in these tissues by the number of chromo- 

 somes in the nucleus and by the mitosis of the divid- 

 ing cell. One hesitates to question the correctness of 

 observation by a protozoologist of Kofoid's calibre 

 but there are so many pitfalls in such work that both 

 biologists and pathologists will await further evidence 

 and confirmation before passing judgment. The na- 

 ture of the lesions in both cases, especially the char- 

 acter of the reaction in Hodgkin's disease, and the 

 dissimilarity to the characteristic amoebic lesion, 

 makes pathologists immediately skeptical that these 

 diseases could be of amoebic origin. 



It seems clear that the disease produced by this 

 organism is virtually limited to the large intestine, 



