CONTENTS 



Chairman's opening remarks 



Sir Charles Harixgtox ...... 1 



Aspects of the problem of drug resistance in bacteria 



by A. C. R. Deax and Sir Cyril Hinshelwood . . 4 



Discussion: Dean, Eagle, Hinshelwood, Lederberg, 



Pollock, Pontecorvo ....... 24 



Indirect selection and origin of resistance 



by L. L. Cavalli-Sforza ...... 30 



Discussio7i : Cavalli-Sforza, Davis, Dean, Gyorffy, 

 Hinshelwood, Hotchkiss, Kunicki-Goldfinger, 

 Lederberg, Pontecorvo, Yudkin .... 40 



Genetic aspects of drug resistance 



by M. Demerec ....... 47 



Discussion: Alexander, Davis, Demerec, Hinshelwood, 

 Hotchkiss, Lederberg, Pollock, Pontecorvo, Slonimski, 

 Walker, Yudkin . . . . . . .58 



Inheritance in single bacterial cells 



by W. Howard Hughes ...... 64 



Discussion: Cavalli-Sforza, Davis, Demerec, Eagle, 

 Hayes, Hughes, Ierusalimsky, Lederberg, Pontecorvo, 

 Stocker, Yudkin ....... 71 



Penicillin-induced resistance to penicillin in cultures of 



Bacillus cereus 



by M. R. Pollock 78 



Discussion : Alexander, Barber, Davis, Hayes, Hotchkiss, 

 Knox, Lederberg, Pollock, Pontecorvo, Slonimski, 

 Stocker ......... 96 



Directed hereditary changes of fermentative properties of 

 yeast by a specific substrate 



by K. V. KossiKOV ....... 102 



Discuss^ion : Harington, Ierusalimsky .... 136 



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