Multiple Mechanisms of Drug Resistance 147 

 reasons, we believe that the increase is due to phenotypic 

 adaptation. 



lOO 



I CYCLE 



I CYCLE 



4.0 



60 



80 



lOO 



I CYCLE 



15 40 60 60 80 lOO I20 



Time(min5) Timelmins) 



A cooling starts after 120 min. from inocu ation 

 B cooling starts after 90 min. from moculation 

 C cooling starts after 70 min. from inoculation 

 D cooling starts after 60 min. from inoculation 

 Time from returning the flasks to 37°C after cooling. 



As well as this moderate increase in resistance of a large 

 proportion of the cells, there was a rise in the number of cells 



