SUBJECT INDEX 



Adaptation, cvtochrome oxidase, 

 221-224 

 during lag phase in media contain- 

 ing new substrates or antibac- 

 terial agents, 13, 14 

 genetic, 30-46 

 maltozymase, 225-229 

 of bacterial populations, 32, 33 

 phenotypic, 142-152 

 "physiological", 16 

 to drugs, accelerated, 15, 16 

 new carbohydrate sources, 10 

 proflavine resistance in Bad. 

 lactis aerogenes, 142-145 

 in Escherichia coli, 141-164 

 Adaptive enzymes, production of, 



by yeasts, 128-135 

 Aerobacter aerogenes (see also Bad. 

 lactis aerogenes), acetate as car- 

 bon source, 9 

 adaptation to D-arabinose, 8 

 chloramphenicol, 9 

 proflavine, 9 

 propamidine, 9 

 sulphanilamide, 9 

 Agar, semi-solid, use of, 241, 242 

 Alkylating agents, mutagenic, 

 294^322 

 reaction with anions, 316 



carboxyl groups, 297, 298 

 DNA, 308-312 

 nucleic acids, 300-305 

 nucleoproteins, 305-307 

 phosphate groups, 307, 



308 

 proteins, 296-299 

 proteins and nucleic acids, 



294^322 

 RNA, 307, 308 

 radiomimetic, 294^322 

 2?-Aminobenzoate, 167,171,172,187, 



188, 190, 191, 193 

 7)-Aminosalicylic acid, antituber- 

 culous effects of, 3 

 resistance in Bacillus megaterium, 

 55 



Anions, reaction of alkylating agents 

 Mith, 316 



Antibiotics, physiological adapta- 

 tion of bacteria to, 251-261 



D-arabinose, adaptation of Aero- 

 bacter aerogenes to, 8, 13, 14 

 Escherichia coli K12 to, 13 

 as sole carbon source, 13, 14 

 utilization by B. coli, 8 



D-arabinose- agar, development of 

 Bad. ladis aerogenes on, 11 



Average clones test, 33 



Bacillus cereus, 266 



penicillin-induced resistance to 

 penicillin in cultures of, 78- 

 101 

 penicillin resistance in, 246, 247 

 Bacteria, aspects of drug resistance 

 in, 4^29 

 identification of genetic and non- 

 genetic variation in, 280-293 

 physiological adaptation to anti- 

 biotics, 251-261 

 Bacterial cells, single, inheritance in, 

 64-77 

 populations, adaptation of, 32, 33 

 Bacterium coli, stability and reversi- 

 bility in, 8 

 Bacterium coli mutabile, adaptation to 

 chloramphenicol, 14 

 adaptation to lactose, 13, 14 



streptomycin, 14 

 development on lactose-agar, 



11 

 Lac+ and Lac- strains, 9, 26, 

 29 

 Bacterium lactis aerogenes (see also 

 Aerobacter aerogenes), 

 adaptation to lactose, 

 13, 14 

 proflavine resistance, 8, 



15, 16, 142-145 

 sodium azide, 15, 16 

 streptomycin, 14 

 sulphanilamide, 8 



347 



