348 



Subject Index 



Bacterium lactis aerogenes, 



development on D-arabinose- 



agar, 11 

 reversibility, in presence of 



phenols, 8 

 stability and reversibility in, 8, 

 9 

 Bacillus megaterium, adaptation to 

 increased concentrations of 

 norsulphazol, 138 

 isoniazid and PAS resistance in, 

 55 

 Bacteriophage, 21, 33, 34, 49, 200 



Carboxyl groups, reaction of alky- 

 lating agents with, 297, 298 

 CB 1506 and CB 1528, 290 

 CB3025, 311, 312 

 Chlorambucil, 303, 304, 306, 307 

 Chloramphenicol, adaptation of 

 Aerobacter aerogenes to, 9 

 Bad. coli mutabile to, 14 

 resistance of Esch. coli to, 21, 35-40 

 Clonal variation, 160, 242, 283 

 Clostridium aceto-butylicum, adapta- 

 tion to fermentation of 

 xylose, 136, 137 

 increased concentrations of 

 butanol, 136-139 

 Cof actors of enzymic adaptation, 



210-232 

 Colicogenic factors, 323-325 



immunity by transfer of, 329-332 

 Colicins, genetics of mechanisms of 



resistance to, 323-338 

 Concentration by limiting dilution, 



3^^-40 

 Crosslinking of DNA, 308-312 

 of nucleoproteins, 317 

 role in mutagenicity, 312, 313 

 Cycles of adaptability to resistance, 



148-164 

 Cytochrome oxidase adaptation, 



221-224 

 Cytoplasmic changes, 7, 8 

 inheritance, 32 

 mutations, 284-286 



5-Dehydroquinic acid, 173, 174 

 5-Dehydroshikimic acid, 173, 174 

 Deoxyribonucleate, 183-186, 194r- 



196, 200, 207, 245, 247, 249, 281, 



282 

 Deoxyribonucleic acid, 4, 5, 53 



Deoxyribonucleic acid, 



transformation experiments with, 



157-160, 163 

 intramolecular crosslinking of, 



308-312 

 possible significance of "hidden 



breaks" in, 313-316 

 reaction of alkylating agents 



with, 308-312 

 Drosophila, 296, 320 



induction of phenocopies in, 288 

 Drug resistance, accelerated, 15, 16 

 acquired, multiple mechanisms 



of, 141-164 

 fluctuation tests, 20 

 graded response, 14, 15 

 heritable changes in, 31 

 in bacteria, adaptational aspects 



of, 4^29 

 indirect selection and origin of, 



30-46 

 in Mycobacterium tuberculosis, 



241-250 

 in Serratia marcescens, 233-237 

 mass-number relations, 9, 10 

 Mendelian analysis, 52, 53 

 mutability, 50-52 

 of staphylococci, 262-279 

 papilla formation, 17-20 

 "penicillin" pattern, 54 

 phenotypic expression of genes 

 determining, 197-209 



mechanism of, 165-182 

 physiological mechanisms of , 165- 



182 

 pre- or postadaptation, 31, 32 

 stability and reversibility, 8, 9 

 "streptomycin" pattern, 54 

 test for presence of mutant forms 



in massive inocula, 10, 11 

 time-number relations, 11, 12 

 transformation and transduction 



analyses, 53 

 Drugs, accelerated adaptation to, 15, 

 16 

 binding or adsorption of, by resis- 

 tant and non-resistant cells, 16- 

 17 

 Dulcitol, adaptation of Escherichia 



coli K12 to, 13 

 Duponol, 159 



Enzyme adaptation in staphylo- 

 cocci, 266-268 

 Enzyme reactions, 5 



