Subject Index 



349 



Enzymes, adaptive, production by 

 yeasts, 128-135 

 evolution of, 94, 95 

 induced formation of, 78-101 

 qualitatively altered, 1G8-172 

 thermostability of, 93 

 Enzymic adaptation, cofactors of, 

 210-232 

 organization of cell, 21 

 Epoxide, 294 {see also Alkylating 



agents) 

 Escherichia coli, 50, 51, 52, 200, 204, 

 208, 251, 293 

 adaptation to proflavine resist- 

 ance in, 141-164 

 chloramphenicol resistance in, 



35-40 

 demonstration and isolation of 

 pre-existing mutants, 156, 157 

 pantothenate - synthesizing en- 

 zyme of , 93 

 production of colicins by, 323-325 

 resistance to chloramphenicol, 21 

 streptomycin resistance in, 35-40 

 "training" and "reversion" in, 



141, 142 

 transformation to proflavine re- 

 sistance in, 157-160 

 Escherichia coli B, 66, 68 



phage-resistant forms of, 16 

 Escherichia coli K 12, 276 



adaptation to D-arabinose, 13 



dulcitol, 13 

 effects of starvation and cool- 

 ing, 252-261 

 Ethylene imine, 294 (see also Alky- 

 lating agents) 

 Expression, phenotypic, 197-209 



Fermentative properties of yeast, 

 directed hereditary changes of, 102- 

 140 



Fluctuation tests, 20, 33, 49 



Genes determining various types of 

 drug resistance, phenotypic ex- 

 pression of, 197-209 

 Genetic adaptation, 30-46 



and metabolic mechanisms under- 

 lying sulphonamide resistance, 

 183-196 

 non-genetic variation in bacteria, 

 280-293 

 aspects of drug resistance, 47-63 



Genetics of mechanisms of resistance 

 to colicins, 323-338 



Growth rate as indication of sensi- 

 tivity and resistance, 64—77 



Heredity, stable, 6, 8 

 Heritable changes in drug resist- 

 ance, 31 

 Hetrazan, 1 

 p-Hydroxybenzoic acid, 171, 172 



Immunity by transfer of colicino- 



genic factors, 329-332 

 Induction of enzymes, 78-101 

 Indirect selection and origin of 



resistance, 30-46 

 Inheritance, cytoplasmic, 32 



in single bacterial cells, 64-77 



"Lamarckian", 152-156 



origin of, 47-63 

 Invertase, production by yeasts, 



128-135 

 Isoniazid, 3 

 Isoniazid resistance, 50 



in Bacillus megaterium, 55 

 Mycobacterium tuberculosis, 

 241-250 



Klebsiella pneumoniae, 70, 324 



Lactose, adaptation of Bad. coli 

 mutabile to, 13, 14 

 Bact lactis aerogenes to, 13, 14 

 Lactose -agar, development of Bact. 



coli mutabile on, 11 

 "Lamarckian" inheritance, 152- 



156 

 Leprosy, chemotherapv of, 2 

 Lethals, 76 

 Long forms of cells due to sensitivity 



to environment, 66, 67 



Maltozymase adaptation, 225-229 

 Mass-number relations, 9, 10 

 Megacine, 337 

 Mendelian analysis, 52, 53 

 Mesyloxy, 294 (see also Alkylating 



agents) 

 Metabolic interference, Woods- 



Fildes hypothesis of, 3 

 Mustard gas, 294 (see also Alkylating 



agents) 



