350 



Subject Index 



Mutability, 50-52 



Mutagenic alkylating agents, 294- 

 322 



Mutant forms in massive inocula, 

 tests for presence of, 10, 11 



Mutants, concentration by limiting 

 dilution, 34-^0 

 demonstration and isolation of pre- 

 existing, 15G, 157 

 fluctuation tests, 20, 33, 49 

 mass-number relations, 9, 10 

 papilla formation, 17-20 

 pre-existent, 9 

 resistant to streptomycin, 50, 51, 



52 

 selection of , 4, 22 

 time-number relations, 11, 12 



Mutational changes in yeast, in- 

 duced, 102-140 



Mutations, 7 

 induction of, 7 

 induced "petite", 215-221 

 "spontaneous," 80-82 

 spontaneous "petite," 229 

 to proflavine resistance in Esch- 

 erichia coll, 141-164 



Mycobacterium tuberculosis, distribu- 

 tion of drug-resistant individuals in 

 cultures of, 241-250 



Neurospora, 93, 284, 287, 319 

 crassa, 51 



Nitrogen mustards, 294 (see also 

 Alkylating agents) 



Nuclear division, 7 



Nucleic acids, reactions of mutagenic 

 alkylating agents with, 294-322 



Nucleoproteins, reaction of muta- 

 genic alkylating agents with, 305- 

 307 



Papilla formation, 17-20 



Paramecium, 284 



Passive type of resistance, 21, 22 



Penicillin, resistance in Staph, 

 aureus, 49 



Penicillin - dependent staphylo- 

 cocci, 263 



Penicillin-induced resistance to 

 penicillin in cultures of B. cereus, 

 78-101 



Penicillin-resistant staphylococci, 

 49, 263 



Penicillin -tolerant staphylococci, 



262, 263 

 Penicillinase, 78-101 



activity, micro-assay of, 84 

 production by staphylococci, 262- 

 279 

 Permeability changes, 172-179 

 Permeases, 175 

 Permeation systems, specific, 172- 



179 

 Phage resistance, 21, 49 



indirect selection in, 33, 34 

 Phenocopy, 282 

 Phenols, 8 



Phenotypic adaptation, 142-152 

 delay, 7 



expression, kinetics of, 197-209 

 of genes determining drug resis- 

 tance, 197-209 

 lag, 197 



mechanisms of resistance, 165- 

 182 

 Phosphate groups, reaction of 



alkylating agents with, 307, 308 

 Pneumococci, sulphonamide resis- 

 tance in, 183-196 

 disseminative transforma- 

 tions, 184^186 

 Population, distribution of sensitiv- 

 ity in, 64-77 

 Polyhydroxy compounds, specific, 

 as cofactors of enzymic adaptation 

 and its inheritance, 210-232 

 Preadaptation theory, 33 

 Pre- or postadaptation, 31, 32 

 Proflavine, adaptation of Aerobacter 

 aerogenes to, 8, 9, 15, 16 

 resistance in Bad. lactis aerogenes, 

 142-145 

 Escherichia coli, 141-164 

 Propamidine, adaptation of Aero- 

 bacter aerogenes to, 9 

 Propiolactone, 294 {see also Alky- 

 lating agents) 

 Proteins, reactions of mutagenic 



alkylating agents with, 294-322 

 Pseudomonas, 208 



production of pyocin by, 337 



Radiomimetic alkylating agents, 



294-322 

 Replica plating, 34, 50 

 technique of, 20-22 

 Resistance cycles, 148-164 

 Resistant variants, origin of, 48-50 



