Subject Index 



351 



Reversibility and stability, 8, 9 

 Ribonucleic acid, 249, 281, 282 



reaction of mutagenic alkylating 

 agents with, 307, 308 

 RNA (see Ribonucleic acid) 



Saccharomyces carlsbergensis, 126 

 Saccharomyces cerevisiae, 119, 124, 127, 



128, 135 

 Saccharomyces chodati, 124, 127, 129, 



134 

 Saccharomyces ellipsoideus. 111, 113, 

 114, 116, 124, 125, 127, 128, 134, 

 135 

 Sacchoromyces globosus, adaptation to 

 fermentation of maltose, 

 113-116 

 fermentationof sucrose, 103- 

 113 

 induced mutational changes in, 

 102-140 

 Saccharomyces heterogenicus, 129 

 Saccharomyces paradoxus, adaptation 

 to fermentation of maltose and 

 simple dextrins of malt-wort, 116- 

 120 

 Saccharomyces prostoserdovi, 129 

 Salmonella para B, 324 

 Salmonella typhi, 324 

 Scdmonella typhimurium, 51 

 Selection, indirect, and origin of 



resistance, 30-46 

 D-Serine, inhibition of pantothenate 



production by, 176, 177, 178 

 Serratia marcescens, 318 



development of resistance to 

 streptomycin in, 233-237 

 Shigella sonnei, 323, 324 

 Shikimic acid, 173, 174 

 Single bacterial cells, inheritance 



in, 64-77 

 Sister cells, variation between, 64- 



77 

 Sodium azide,201, 204 



adaptation of Bad. lactis aero- 

 genes to, 15, 16 

 Sperm heads, 300 



reaction with alkylating agents, 

 305-316 

 Spores, transmission of resistance 



through, 136-140 

 Stability and reversibility, 8, 9 

 Staphylococci, drug resistance of, 2, 

 262-279 

 enzyme adaptation in, 266 



Staphylococci, 



penicillinase production by, 262- 



279 

 penicillin-dependent, 263 

 penicillin-resistant, 263 

 penicillin-tolerant, 262, 263 

 spontaneous mutation in, 266-268 

 Staphylococcus aureus, adsorption of 

 streptomycin, 17 

 characteristics of penicillin-de- 

 stroying cultures isolated from 

 penicillin-sensitive, 269-271 

 isolation of penicillin-destroying 

 variants from penicillin-sensi- 

 tive strains of, 268, 269 

 Streptomycin, 3 



adaptation of Bad. ladis aerogenes 



to, 14 

 adsorption isotherms, 17 

 resistance to, 14, 21, 50 

 in Escherichia coli, 35-40 



Serratia marcescens, 233-237 

 indirect selection in, 33, 34 

 Substrate, specific, directed here- 

 ditary changes of fermentative 

 properties of yeast by, 102-140 

 Sulphanilamide, adaptation of 



Aerohader aerogenes to, 8, 9 

 Sulphonamide, inhibition of cell 

 gro^\i;h, 189-191 

 resistance in pneumococci, 183-196 

 disseminative transforma- 

 tions, 184-186 

 nature of, 187-189 

 Sulphur mustards, 294 {see also 

 Alkylating agents) 



Tetroses, 212 



[S-Thiomethyl galactoside (TMG), 



175, 176 

 Threonine, 201 



Time-number relations, 11, 12 

 Transduction analysis, 53 

 Transformation and transduction 

 analyses, 53 

 of pneumococci to sulphonamide 



resistance, 183-196 

 to proflavine resistance in Esch- 

 erichia coli, 141-164, 157-160, 

 163 

 Triacrylformal, 295, 311, 312 

 Tuberculosis, experimental, chemo- 

 therapy of, 2 {see also Alycobac- 

 terium tuberculosis) 



