32 



MACROMOLECULAR COMPLEXES 



If the water dialysis is carried out with lower concentrations of 

 the glycoprotein, a mixture of FLS and native-type ' fibrils is ob- 

 tained (Highberger et al., 1951). At still lower concentrations, only 

 native-type fibrils are obtained. The system glycoprotein-collagen 

 thus nicel\- illustrates the manner in which binding of a second 

 component modifies the charge distribution at a given pH and ionic 

 strength and changes the type of ordered interaction favored. 



Fig. 13. SLS-type aggregate of whole polymeric type from a solution 

 sonically irradiated 240 min, showing end-to-end linkages of the type A'-A' 

 and B'-B'. Stained with PTA. X 100,000. (From Hodge, 1959b.) 



J^,//l 



Fig. 14. SLS aggregates from a solution sonically irradiated 240 min, 

 showing formation of ribbon-like fragment monomeric forms of the type A'C. 

 Stained with PTA. X68,000. (From Hodge and Schmitt, 1958.) 



■^ The term "native-type" refers to the noniial aggregation state of TC in vivo, i.e., 

 with an axial period of ca. 700 A. 



