Chapter VII — 1 23 — Antagonistic Properties 



in many forms of this disease affecting the human body. The cul- 

 minating point of these studies was reached in 1946, with the publica- 

 tion by the Committee on Chemotherapy (212) of the reports of one 

 thousand cases in the clinical evaluation of streptomycin and of the first 

 one hundred cases of tuberculosis treated with streptomycin (174). 

 Streptoviycin-'prodzicing strains of S. grisetis.— An organism under 



Table 26: Growth and chemical chanties produced hy S. griseus 



under submerged conditions (10]): — 



Calculated as milligrams in 100 ml culture 



the name Actinomyces griseus was first described by Krainsky in 

 Russia in 1914. In studies of the soil actinomycetes carried out by 

 Waksman and Curtis in 1915, an organism was isolated from a Cali- 

 fornia soil. This organism appeared to be similar to A. griseiis Krain- 

 sky, so far as could be determined by comparison with the published 

 description of the organism, but not by comparison of the actual cul- 

 tures. In September 1943, two strains of S. griseus were isolated (390) 



Table 27: Nitrogen distribution in cultures of S. griseus (481): — 

 Per 250-ml portions of broth* 



J* Broth contained per liter 5 gm peptone, 5 gm meat extract, 5 grn glucose and 5 gm NaCl. 

 t Total nitrogen in original broth 280 mg. 



