Chapter VII _ ] 3 1 _ Antagonistic Properties 



of the literature (455) and of the use of this antibiotic in the treatment 

 of numerous infections (456) have already been published. The ex- 

 tensive utilization of streptomycin in tuberculosis has stimulated numer- 

 ous surveys of the production of antitubercular agents by actinomycetes. 

 Both members of the NocanUa (105, 258) and of the Strepomyces 

 (193, 471) genera have been investigated in detail. 



Among the most important problems that have arisen in connection 

 with the use of streptomycin is the development of resistance among 

 bacteria on contact with this antibiotic (476), and especially the develop- 

 ment of streptomycin-dependent strains (300, 331). 



