178 THE ANTIBIOTICS 



G. Substances active against tumor cells. 



Antitumor factors 

 Antitumor substance 289 

 Sarkomycin 



Key II to the Identification of Antibiotics of Actmomycetes 



A. Substances active primarily against gram-positive bacteria. 

 I. Active mainly against mycobacteria. 



1. Active only against mycobacteria. 



a. Colorless, no activity in vivo. 



Actithiazic acid 



b. Reddish-colored. 



Nocardamin 



c. Incompletely described. 



Antismegmatis factor 

 Antiphlei factor 



2. Active also against true bacteria. 



a. Highly water-soluble. 



Viomycin 



Vinactin 



Nocardin 



b. Slightly water-soluble. 



Amicetin 

 Vinacetin 

 Camphomycin 



c. See p. 179 for erythromycin and carbomycin, p. 180 for cin- 

 namycin, p. 180 for antibiotics X-206, X-464 and X-537A, 

 and p. 181 for rhodocidin. 



II. Strongly active also against fungi. 



1. See group C for endomycin, helixin, musarin, nigericin. 



2. See actinomycin p. 179, and cardicin p. 180. 



III. Strongly active also against Treponemataceae. 



1. Basic, not very toxic. 



Puromycin 



2. Acidic, toxic 



Borrelidin 



IV. Strongly active also against gram-negative bacteria of the genus 

 Hemophilus. 



1. Containing no nitrogen. 



Exfoliatin 



2. Containing nitrogen, 

 a. Very toxic to mice. 



Luteomycin 



