212 THE ANTIBIOTICS 



Toxicity: LD 6 o (mice), intravenous, 625 mg/kg. 



Utilization: None. 



Reference: Taira, T., and Fujii, S., J. Antibiotics (Japan), 6, 1952, 185-187. 



Micromonosporin 



Produced by: Micromonospora sp. 



Method of extraction: Precipitation by saturation with ammonium sulfate 



and dialyzation of the precipitates against water. 

 Chemical and physical properties: Protein associated with a carbohydrate. 

 Biological activity: Active against gram-positive bacteria. Not active against 



gram-negative bacteria. 

 Toxicity: No data. 

 Utilization: None. 

 Reference: Waksman, S. A., Geiger, W. B., and Bugie, E., J. Bacteriol., 



68, 1947, 355-357. 



Miramycin 



Produced by: Streptomyces mirabilis. 



Method of extraction: Unknown. 



Chemical and physical properties: Heat stable. 



Biological activity: Active against gram-positive and gram-negative bac- 

 teria. 



Toxicity: Said to be nontoxic. 



Utilization: Unknown. 



Reference: Ruschmann, G., Die Pharmazie, 7, 1952, 542-550, 639-648, 

 823-831. 



Moldin 



Produced by: Streptomyces phaeochromogenus. 



Method of extraction: Extraction of broth or the mycelium with ethyl ace- 

 tate, concentration in vacuo to a syrup. The syrup is washed with 

 petroleum ether and water. The residue is dissolved in ethanol and 

 precipitated with water. 



Chemical and physical properties: Soluble in ethanol and ethyl acetate. 

 Slightly soluble in petroleum ether, ether, and benzene. 



Biological activity: Active against Candida, Trichophyton, Histoplasma cap- 

 sulatum, and Cryptococcus neoformans. 



Toxicity: LD (mice), intraperitoneal, about 10 mg/kg. 



Utilization: None. 



Reference: Maeda, K., Okami, Y., Taya, 0., and Umezawa, H., J. Antibiot- 

 ics (Japan), 6, 1952, 465; Japan. J. Med. Sci. Biol. 5, 1952, 327-339. 



