76 ANTIBIOTIC ACTION OF ANTAGONISTS 



TABLE 8. BACTERIOSTATIC SPECTRUM OF PENICILLIN 



DILUTIONS AT WHICH INHIBITORY 



ORGANISM AFFECTED EFFECTS WERE OBSERVED 



Complete Partial None 



N. gofiorrhoeae^ 2,000,ooo > 2,000,000 > 2,000,000 



"N . meningitidis 1,000,000 2,000,000 4,000,000 



S. aureus 1,000,000 2,000,000 4,000,000 



S.fyogenes 1,000,000 2,000,000 4,000,000 



B.anthracis 1,000,000 2,000,000 4,000,000 



A.bovis 1,000,000 2,000,000 4,000,000 



CI. tetani\ . i ,000,000 



CI. welchii 1,500,000 



CI. sefticum 300,000 1,500,000 7,500,000 



CI. oedematiens 300,000 1,500,000 



S.viridansX 625,000 3,125,000 



Pnetimococcus\ 250,000 500,000 1,000,000 



C. difhtheriae (miiis) 125,000 625,000 



C. difhtheriae {gravis) 32,000 64,000 128,000 



S. gartneri 20,000 40,000 8 0,000 



S.tyfhi 10,000 30,000 90,000 



Pneu7nococcus\ 9,000 27,000 



Anaerobic Streptococcus^ 4,000 8,000 16,000 



P. vulgaris 4,000 32,000 6o,000 



S. viridans% 4,000 8,000 1 6,000 



P.festis 1,000 100,000 500,000 



S. iyfhimurium <^ 1,000 8,000 1 6,000 



S.faratyfhiB • <I,000 5,000 10,000 



Sh. dysenteriae 2,000 4,000 8,000 



Br. abortus 2,000 4,000 8,000 



Br.melitensis <i,ooo 2,500 10,000 



Anaerobic streptococcus <(4,000 <(4,ooo 4,000 



V. comma <^ 1,000 1, 000 2,000 



E.coli <i,ooo <i,ooo 1,000 



K. pieumoniae <^ i ,000 < i ,000 i ,000 



Ps. aeruginosa < 1 ,000 < 1 ,000 i ,000 



M. tuberculosis <i,000 < 1,000 1,000 



L. icterohaemorrhagiae <^ 3,600 <^ 3,600 35600 



From Abraham et al. (5). Crude penicillin preparation was used. 



•Another strain was inhibited only up to 32,000. 



t Grown in Lemco broth; in beef broth complete inhibition reached only 100,000. 



X In Pneumococcus, S. viridans, and anaerobic streptococci, different strains appear at different 



levels in the table. 



