FUNGI AS ANTAGONISTS 



□ su 



eFACE CULTURE 

 SUBMERGED CULTURE 



D. 20 



PENICILLIUM SUBSTRAIN 



Figure 15. Comparative production of penicillin by substrains of P. chry- 

 sogenum 1951.B25 in surface culture and submerged culture. From Raper 

 and Alexander (764). 



As a result of these studies the following conclusions were reached 

 (763,764): 



1. The capacity to produce penicillin as a metabolic product is a group- 



specific rather than a strain-specific character. 



2. Different members of the P. notatum-chry so genum group vary 



greatly in their capacity to produce penicillin. 



3. Special strains are particularly suited for certain types of penicillin 



production. 



For surface production of penicillin, no strain was found to be better 

 than the original Fleming culture that has been freed from degenerate, 



