ANTIBIOTICS AS CHEMOTHERAPEUTIC AGENTS 



291 



blood, urine, ascitic fluid, pleural fluid, aqueous humor, vitreous 

 humor, amniotic fluid, and bile. Small amounts of the drug appear in 

 the spinal fluid in healthy individuals, but in a single case of Hemoph- 

 ilus in-jiuenzae meningitis the spinal fluid contained 25 ng per cc. 



TABLE 48. COMPARISON OF THE EFFECT OF STREPTOMYCIN AND 



PENICILLIN ON INFECTION WITH LEPTOSPIRA 



ICTEROHAEMORRHAGIAE IN HAMSTERS 



From Heilman (399). 



•Streptomycin and penicillin are measured by totally different systems: a streptomycin unit is a 



milliliter dilution unit against E. colt; an Oxford unit of penicillin is 1:50,000 against S. aureus. 



TABLE 49. EFFECT OF STREPTOMYCIN UPON THE DEVELOPMENT OF 

 HUMAN TUBERCULOSIS IN GUINEA PIGS 



From Feldman, Hinshaw, and Mann (250). 



