Neural Mechanisms of Decision Makirrg 263 



During Blockc3dc of CAR After Rcserpinc 



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Fig. 13. Records obtained in response to ten per second flicker after performance 

 of the avoidance response to six per second flicker was blocked by injection of 

 reserpine (1007/kg). (From John, E. R. and Killam, K. F.: J. Nerv. Ment. Dis., 



737.- 183-201, 1960.) 



was observed in the recorded waveforms. This change was a shift 

 from rounded "waves" to more sharply peaked spikes and was 

 foUowed one or two seconds later by performance of the conditioned 

 response. 



Some indication of the possible functional relevance of the slow 

 six per second centralis lateralis waves seen during the approach 

 signal after avoidance training is provided by the data in Figure 13. 

 When performance of the avoidance response to the six per second 

 TCS was completely blocked after administration of 100 7/kg. of 

 reserpine, presentation of the ten per second TCS no longer elicited 

 the previously marked slow potentials in centralis lateralis and 

 elsewhere, but instead resulted in the appearance of massive 

 labeled responses at ten per second frequency. Wlien 0.5mg/kg. of 

 amphetamine was administered to this cat, the reserpine blockade 

 of the conditioned avoidance response performance to the six 

 per second TCS was completely reversed in a few minutes. Presenta- 

 tion of the ten per second TCS for the lever pressing response to 



