222 v * ce a PP rec i ate d what he was doing. Not only "interested" in 

 his researches, satisfied with his progress and excited by the 

 "possibility of finding the causal agent which has baffled the 

 world," Russell Wesley Raynor said (September 3, 1918) that 

 he "would be very much gratified" if Wherry would continue 

 his work at the laboratory in Pikeville. "Is it not possible that 

 you can do so?" he asked. Before leaving Kentucky Wherry 

 wrote his daughter, now aged nine (September 11, 1918) : 



Thank you for your pretty letter written with a quill pen. 

 That was quite an idea! Two hundred years ago quill pens were 

 the fashion. In fact they did not have anything else excepting 

 pens of split reed and these are still used in India. The old poets 

 used quill pens and one of them must have been an ancestor 

 of yours for you wrote me, "The water is very pretty. When 

 the sun shines on it, it's silver." That's a beautiful idea, I think. 

 . . . Some of the people here use very bad English for they 

 say, "He's most ez tall ez I're." I may leave here Saturday. 



ON arrival in Cincinnati the paper met him which was to 

 be his last for a time. Eight pages told of A respiratory 

 stimulant and toxic substance extractable from lung tissue 

 [63]. It had been received by Hektoen in March. Said 

 Wherry: 



The interesting method we shall describe of producing 

 accelerated respiration or death was discovered accidentally 

 in an experiment with tuberculous tissue from a rabbit's 

 lung. A piece of tissue filled with tubercles was ground . . . 

 suspended in salt solution . . . injected intravenously into 

 another rabbit which immediately fell on its side . . . and 

 died a few seconds later. 



He omitted relating earlier experiments during which he 

 had thought the effects due to a toxine of the tubercle bacil- 

 lus. Tests showed that "it played no part." In other words 

 the extract of normal lung did the mischief. He explained 

 how little was required. A given weight of rabbit lung was 

 crushed in ten times its volume of salt-water. But "one cc 

 of this crude extract did not really contain 0.1 gramme of 

 lung tissue, for most of the tissue remained in the mortar." 



