be practiced. This called for tiny doses of the vaccine prepared ^ S S 

 from all those strains to which the patient had proved sensi- 

 tive; repeated day after day until "immunity" had been 

 produced. This point was reached when increasing doses of the 

 vaccine no longer occasioned a local reaction. The patient had 

 then learned to meet his poison — a matter proved by the cessa- 

 tion of symptoms for which he had originally consulted his 

 doctor. 



A paper setting forth these ideas, after years of work, 

 appeared in 1928 [74]. Here was description of his "sensi- 

 tivity" test, the rules for the selection of proper "antigens," 

 illustrative case histories of patients, particularly of those who 

 had been the victims of "mixed" infection — sinusitis, asthma, 

 colitis, skin eruption. 



He repeated his beliefs in a chapter written for E O Jordan's 

 Newer knowledge of bacteriology and immunology [75], 

 entitled 'Phagocytes and phagocytosis in immunity. Preceding 

 his views were clipped history and fine English. Recalling "the 

 ardent contest between the champions of the humoral theory 

 of immunity and those who maintain that certain body cells 

 play an equally important part" he held both parties to have 

 right on their side. 



When foreign bodies of a varied nature, including parasitic 

 microorganisms, gain entrance to the tissues, they are invested 

 by certain cells derived from the fixed tissues or from the cir- 

 culating blood. . . . When this ingestion (phagocytosis) is 

 followed by digestion the host recovers, otherwise it succumbs. 

 . . . Many investigators question the ability of the phago- 

 cytes to kill the parasites. Some maintain that the parasites are 

 killed first by normal or acquired bactericidal substances and 

 then ingested and removed as so much foreign debris. 



He summarized briefly and pungently the "more important 

 steps in the growth of our knowledge." Starting with the 

 phagocytic half of the total problem, he reviewed what we 

 know of the anatomy and the origin of the tissue and blood 

 cells involved in the process. The Kupff er cells of the liver were 

 to him "specialized endothelial cells within the capillaries 

 anchored out into the blood stream by guy ropes of cyto- 

 plasm." Pretty morphology, which did not, however, blind 



