2 7 2 ^ ever > Lee Foshay had developed new cultural and staining 

 methods for B tularense; some of the other men had proved 

 real chemistry to be hidden in the biological. 



September 24, 1930, William H Howell (seventy, head of 

 U S's thought in physiology for forty years, author of the 

 country's standard text upon the subject, and now the gentle- 

 manly director of Hopkins's school of hygiene) wrote: "... 

 delighted to know that you are willing to give one of our 

 De Lamar lectures. Will you please send me at least a provi- 

 sional title?" Wherry announced: Hypersensitivity to bac- 

 terial proteins and its role in susceptibility and immunity; 

 with the date set for March 31, 1 9 3 1 . It was printed [80], to 

 represent, perhaps, the most succinct statement of his scien- 

 tific philosophy ever made — or that succeeding years were to 

 permit him to make. Essentially technical, some of the follow- 

 ing items were more general in their interest. 



He reaffirmed his notions of the difference between infesta- 

 tion by a potential parasite and infection. To pass from the 

 first to the second required a breaking down of the natural 

 defenses of the body. He restated what were the biological 

 characteristics of the microorganism necessary to such end, 

 illustrating the play involved by detailing his experience in 

 treating inflammation of the eye. "Bacteria localize in the 

 conjunctiva . . . Several times I have treated a beginning 

 pneumococcus infection with a few drops of 1—4000 optochin; 

 the bacteria are killed quickly and healing occurs." But "such 

 good results cannot be obtained if one waits a little longer. 

 ..." Then the infesting parasite becomes infectious and 

 establishes itself within the tissues. "If the resultant edema be 

 great, further invasion is favored and conversely, if it be re- 

 duced by agents which dehydrate colloids the progress of the 

 infection is restrained and the infecting agent overcome by 

 the host." 



What could be done to aid the host? It had to be "desensi- 

 tized"; and this through use of a properly injected, properly 

 prepared vaccine. 



All the toxines of bacteria, as well as similar poisons produced 

 by reptiles and insects, are of such a nature that when injected 

 they give rise to the production of antagonistic substances. 



