280 councu f° r a P er i°d of five years, and he has approved this 

 appointment. 



Hektoen, Hunt, McCollum, Rosenau, Stengel, McCoy were 

 of the crowd. It was pleasant business to be offered a horse in 

 the wagon-train of which he had so often and so irregularly 

 been a part ; but he could not accept. Wayson wrote him from 

 Honolulu (February 8, 193 5) : 



I learned from Fennel [Eric A, ex-U S P H S, now practicing 

 in Hawaii] that you developed complications which put you 

 down again; and that Mrs Wherry suffered a fractured thigh. 

 I write to remind you that the Waysons are hoping hard that 

 you will both soon be well enough to be about. — I sent you 

 recently an article on the epidemiology of leprosy in Hawaii. 

 There are no discoveries in it, but a lot of work establishing or 

 disrupting hypotheses. While the analysis may appear to be 

 only arithmetical, more is involved. 



He and Wherry had long discussed treatment for leprosy. 

 Wayson continued: 



I have tried to desensitize a group of patients by the use of a 

 suspension of organisms obtained from leprous rats — killed 

 with formaldehyde, washed, etc. A control of rat tissue alone 

 produced no ill effects. The results, however, appear to be 

 nil. An intracutaneous test with the same material appears to 

 have specificity, and positive reactions occurred in 80% of 

 24 patients adjudged quiescent or recovering, and in 20% 

 of 60 patients adjudged active or progressing. A large per- 

 centage of those with positive reactions developed a sterile 

 abscess after two to eight weeks ; or among those treated, after 

 the last inoculation. A few who subsequently developed 

 leprous reactions had acute erysipelatous inflammations de- 

 velop at the site of the intradermal test, though there had 

 been only a small (0.5 cm) indolent ulcer at the site previous 

 to the leprous reaction. 



I think I have obtained passage of the rat lepra organism 

 through the unbroken nasal mucous membrane, with sub- 

 sequent infection, in a rat. 



Since 19321 have watched the development of minor neuro- 

 logical findings in the children of leprous parents, and have 

 recently seen the cases proved up with skin and bacteriologic 



