52 



ROBERT H. BROWNSON 



TABLE II 



Cumulative Effects of X-irradiation 



Physical data 



Microscopic 



Neurons 

 Head 

 Rats dosage PRT Purkinje Granule Pyramidal Tuber 



no. (r)"^ (days) cerebellum cerebellum cortex hypothalamus 



Large 

 brain stem 



;a) (b) (C) 



(D) 



(E) 



(f; 



(g; 



(H) 



1820 228 Mild hyper- 

 chromatic 



Mild scat- 

 tered 

 pyknotic, 

 hyper- 

 chromatic 



Scattered 

 hyper- 

 chromatic, 

 pyknotic, 

 mild neuro- 

 fibrillary 

 changes 



Mild to mod- — 

 erate, (PAS) 

 positive 

 globules, 

 mild hyper- 

 chromatic 

 pyknotic 



2000 228 Mild hyper- 

 chromatic, 

 pyknotic 



Mild scat- 

 tered 

 pyknotic, 

 hyper- 

 chromatic 



Scattered 

 pyknotic, 

 mild neuro- 

 fibrillary 

 beading, 

 hyper- 

 chromatic 



Heavy, (PAS) 

 positive 

 globules, 

 hyper- 

 chromatic, 

 pyknotic 



Mild 



chromatolysis, 

 hyper- 

 chromatic, 

 pyknotic 



3000 165 Mild hyper- 

 chromatic, 

 pyknotic 



Moderate 

 scattered 

 pyknotic, 

 hyper- 

 chromatic 



Scattered 

 pyknotic, 

 mild neuro- 

 fibrillary 

 brading 

 hyper- 

 chromatic 



Moderate Mild 

 (PAS) posi- chromatolysis, 

 tive globules, hyper- 

 mild pyknotic, chromatic, 

 hyper- pyknotic 

 chromatic 



4000 158 Mild hyper- Moderate 

 chromatic, scattered 

 pyknotic pyknotic 



hyper- 

 chromatic 



Scattered Moderate 

 pyknotic, (P.^S) positive 



mild, neuro- globules 



fibrillary 

 beading, 

 hyper- 

 chromatic 



moderate 

 hyper- 

 chromatic, 

 pyknotic 



Moderate 

 chromatolysis, 

 hyper- 

 chromatic, 

 pyknotic 



5000 116 Severe Severe Scattered Heavy, (PAS) Moderate 



hyper- scattered mild neuro- positive chromatolysis, 



chromatic, pyknotic, fibrillary globules, hyper- 



pyknotic hyper- beading, hyper- chromatic, 



chromatic cell chromatic, pyknotic 



necrosis pyknotic 



5000 228 



Moderate 

 to severe 

 hyper- 

 chromatic, 

 pyknotic 



Mild 

 scattered 

 pyknotic 

 hyper- 

 chromatic 



Scattered Heavy, (PAS) Moderate 



pyknotic, positive to mild, 



mild neuro- globules, hyper- 



fibrillary hyper- chromatic, 



beading, chromatic, pyknotic 



cell necrosis pyl-^notic 



" Roentgens delivered in air. 

 '' Animals utilized in behavioral studies. 

 <• Animals not utilized in behavioral studies. 



